LFCS Publications

Published LFCS Consortium articles:

Williams, H.D., et al., Toward the establishment of standardized in vitro tests for lipid-based formulations: 1) Method parameterization and comparison of in vitro digestion profiles across a range of representative formulations. Journal of Pharmaceutical Sciences, 2012. 101(9): p. 3360-3380.

Williams, H.D., et al., Toward the establishment of standardized in vitro tests for lipid-based formulations: 2) The effect of bile salt concentration and drug loading on the performance of Type I, II, IIIA, IIIB and IV formulations during in vitro digestion. Molecular Pharmaceutics, 2012. 9(11): p. 3286-3300.

Latest upcoming publication:

Williams, H.D., et al., Toward the establishment of standardized in vitro tests for lipid-based formulations: 3) Understanding supersaturation versus precipitation potential during the in vitro digestion of Type I, II, IIIA, IIIB and IV lipid-based formulations. Pharmaceutical Research, 2013. In press.

Poster presentations:

The LFCS Consortium: 1 - Effect of bile salt concentration on in vitro digestion of a range of lipid-based formulations - AAPS Annual Meeting and Exposition, 2011 Washington

The LFCS Consortium: 2 - Effect of drug saturation level on lipid-based formulation performance during in vitro digestion - AAPS Annual Meeting and Exposition, 2011 Washington

The LFCS Consortium: 3 - Effect of calcium and pancreatin concentration on in vitro digestion of a range of lipid-based formulations - AAPS Annual Meeting and Exposition, 2011 Washington

The LFCS Consortium: 4 - Effect of formulation surfactants on the extent of in vitro digestion of a range of lipid-based formulations - AAPS Annual Meeting and Exposition, 2011 Washington

The LFCS Consortium: 1 - Effect of saturation level of a neutral drug and a weakly acidic drug on the performance of lipid-based formulations during in vitro digestion - AAPS Annual Meeting and Exposition, 2012Chicago

The LFCS Consortium: 2 - Toward the development of a new performance-based lipid formulation classification system (LF-P-CS)- AAPS Annual Meeting and Exposition, 2012Chicago

The LFCS Consortium: 3 - Effect of saturation level of a highly lipophilic drug on the performance of lipid-based formulations during in vitro digestion- AAPS Annual Meeting and Exposition, 2012Chicago

The LFCS Consortium: 4 - Solubilisation of a weak base during in vitro digestion of 8 lipid-based formulations under 3 different conditions- AAPS Annual Meeting and Exposition, 2012Chicago